ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Pediatr 2018;193:134-138.e1Obesity promotes visceral fat deposition, which may result in profound metabolic consequences that contribute directly to insulin resistance, and risk of cardiovascular disease and malignancy. Obese individuals are at increased risk of fatty liver disease, which can lead to steatohepatitis and subsequently advanced liver fibrosis. Less...

qhfka9357@naver.com Integr Med Res 11 (2022) 100832. doi: 10.1016/j.imr.2022.100832Brief Summary: This systematic review found that East Asian traditional medicine (EATM) therapies may have beneficial effects in children with idiopathic short stature, however, high-quality studies are necessary.The authors reviewed 14 studies (...

Nat Commun. 2021 Jan 11;12(1):256. doi: 10.1038/s41467-020-20511-7. PMID: 33431871.These authors report two Mll4 mutant mouse models that exhibited dwarfism and altered development of GHRH−neurons.Inactivating mutations in KDM6A (aka UTX) or KMT2D (aka MLL4) genes result in Kabuki syndrome (KS), whose hallmarks in...

To read the full abstract: J Clin Endocrinol Metab 2018;103:158-168Defects at the GNAS locus give rise to various phenotypes, several of which are associated with subcutaneous ossifications (SCOs), which cause significant morbidity among the affected individuals. A subgroup of patients with paternally inherited GNAS mutations have progressive osseous heteroplasia (POH), characterized by severe he...

To read the full abstract: Nat Commun. 2019 Aug 16;10(1):3696. doi: 10.1038/s41467-019-11667-y. PMID: 31420539.The hypothalamic arcuate nucleus (ARC) controls crucial physiological processes, such as growth, reproduction and energy homeostasis. However, it is unknown how ARC neurons gain their unique cellular identities and what are their developmental relationships. Here, the authors i...

Nature 2020 Dec; 588(7836): 112–117https://go.nature.com/3go7UjOThirst is sensed by two distinct types of stimuli – osmotic and hypovolaemic. The authors show that in mice these two stimuli act via separate mechanisms and neuron types, and lead to distinct drinking behavioural responses. High blood osmolality induces osmotic thirst that drives water consumption. By contrast, hypovolaemia driv...

J Clin Oncol. 2022 May 1;40(13):1439-1449. doi: 10.1200/JCO.21.01841. Epub 2022 Jan 19. PMID: 35044839Brief Summary: This retrospective study showed that children and young adults (< 45 years) treated with radioactive iodine (RAI) for primary Differentiated Thyroid Cancer (DTC) have increased risks for leukemia and solid cancers, particularly beyond 20 years after treatment.<p class="abs...

To read the full abstract: J Nutr. 2020 Jun1;150(6):1405–1412.There is increasing evidence that dairy milk positively affects linear growth, weight and body composition in children, particularly in low- and middle-income countries (1)(2). This effect of milk on growth has been proposed to be mediated by IGF-I (2), (3). The aim of this double-blinded, controlled trial was to evaluate the effect of milk supplements on circulating IGF-I and to...

To read the full abstract: J Bone Miner Res. 2020;35(2):248–260.In brief: This randomized open-label trial in oligoamenorrheic athletes evaluated the effects of transdermal estrogen, oral estrogen or no replacement on bone metabolism, geometry, and microarchitecture. Transdermal estrogen treatment resulted in significantly greater increases in volumetric bone mineral d...

To read the full abstract: PLoS Biol 2018;16:e2004399The hypothalamus plays a central role in the control of numerous physiological pathways and received afferent pathways from the brain and from the periphery. For instance, body temperature changes in peripheral tissues are conveyed to the hypothalamus via the bloodstream. An increase of temperature within the hypothalamus results in an i...